Substrate: Werner syndrome helicase (Werner syndrome helicase)
Seq-ID: Q14191 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-56621   H2AX_HUMAN
MINT-6550777   RAD52_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
G-quadruplex DNA binding,
magnesium ion binding,
manganese ion binding,
protein homodimerization activity,
3`-5` exonuclease activity,
ATP-dependent 3`-5` DNA helicase activity,
ATP binding,
bubble DNA binding,
four-way junction helicase activity,
Y-form DNA binding,
protein complex binding		 centrosome,
nucleolus,
nucleoplasm		 replication fork processing,
response to oxidative stress,
response to UV-C,
base-excision repair,
multicellular organismal aging,
regulation of apoptosis,
telomere maintenance,
DNA synthesis involved in DNA repair,
DNA recombination,
positive regulation of hydrolase activity
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 426 DIAYKSTEHLSPNDNENDTSY - 18669648
HTP
0.82
 - -
0.75
 --
S 440 NENDTSYVIESDEDLEMEMLK - 18669648
HTP
1.00
 - -
0.72
 --
S 453 DLEMEMLKHLSPNDNENDTSY - 18669648
HTP
0.04
 - -
0.75
 --
S 467 NENDTSYVIESDEDLEMEMLK - 18669648
HTP
0.20
 - -
0.67
 --
S 1058 RNWLHKANTESQSLILQANEE - 17525332
HTP
0.84
 - RQC
0.31
 --
S 1141 VQSPEKAYSSSQPVISAQEQE ATM 11252893
LTP
0.60
 MOD_PIKK_1
 - -
0.53
 --
S 1141 VQSPEKAYSSSQPVISAQEQE ATM 10839545
LTP
0.60
 MOD_PIKK_1
 - -
0.53
 --
S 1141 VQSPEKAYSSSQPVISAQEQE - 17525332
HTP
0.60
 MOD_PIKK_1
 - -
0.53
 --
S 1292 LPLMTIGMHLSQAVKAGCPLD ATM 10608806
LTP
0.32
 MOD_PIKK_1
 - -
0.21
 --
S 1400 EEVGINTETSSAERKRRLPVW - 18669648
HTP
1.00
 - -
0.49
 --

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